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Super-TDU (TFA) (1599441-71-0 free base)

CAS No.

Super-TDU (TFA) (1599441-71-0 free base) ( )

Catalog No. M30268 CAS No.

uper-TDU is an inhibitory peptide targeting YAP-TEADs interaction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Super-TDU (TFA) (1599441-71-0 free base)
  • Note
    Research use only, not for human use.
  • Brief Description
    uper-TDU is an inhibitory peptide targeting YAP-TEADs interaction.
  • Description
    uper-TDU is an inhibitory peptide targeting YAP-TEADs interaction. (In Vitro):Super-TDU TFA downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU TFA inhibited cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27.(In Vivo):Super-TDU TFA (intravenous Injection; 50 μg/kg or 500 μg/kg; per day ) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner. Super-TDU TFA (Intravenous Injection; 250 μg/kg 500 μg/kg) has the t1/2α of 0.78 hours and 0.82 hours; the Cmax of 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.
  • Synonyms
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    --
  • Formula Weight
    5394
  • Molecular Formula
    C239H371N66O71S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Jiao S, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014 Feb 10;25(2):166-80.
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